FARNESYLTRANSFERASE INHIBITOR LONAFARNIB SUPPRESSES RESPIRATORY SYNCYTIAL VIRUS INFECTION BY BLOCKING CONFORMATIONAL CHANGE OF FUSION GLYCOPROTEIN

Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein

Abstract Respiratory syncytial virus (RSV) is the major cause of bronchiolitis and pneumonia in young children and the elderly.There are currently no approved RSV-specific therapeutic small molecules available.Using high-throughput antiviral screening, we identified an oral drug, the prenylation inhibitor lonafarnib, which showed potent inhibition

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ANALYSYS OF JAVANESE SCRIPT WRITING ERROR IN THE JAVANESE LANGUAGE COURSE (Study At Elementary School Teacher Education Program University of Nusantara PGRI Kediri Class of 2014)

The ability to write Java script for PGSD students is one of the skills that must be mastered.Remember, THINNING HAIR CONDITIONER the Javanese script is part of the Javanese lesson material that must be taught in primary school.Writing Javanese script, still facing obstacles that is still found a lot of students who have errors writing Javanese scr

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Recalcitrant carbon and nitrogen in agriculture soils with residue accumulation and fertilization under tropical conditions

Soil organic matter has a strong relation to total organic carbon, and about 85% of organic carbon consists of humic substances (HS), classified as humin (HU), humic (HA) and fulvic acids (FA), and denominated as recalcitrant carbon in soil.HS are formed by complex, heterogeneous and polydisperse molecules, which have 115 significant influence on t

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